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Sept. 18, 2008, Mike Burka PDF Print E-mail
2008

Near-Infrared Spectroscopic Detection of Lipid Core Coronary Plaques

Note: Meeting to be held at Goodrich - Details pending

Coronary artery disease is the leading cause of death in the United States and in most developed nations. Most heart attacks appear to be due to the disruption of lipid core lesions, known as Vulnerable Plaques, in the coronary arteries.

A catheter-based Near-Infrared Spectroscopy (NIRS) system has been developed and is now in use clinically for the detection of lipid core plaques in the coronary arteries. The chemical composition of the vascular wall can be measured through blood during percutaneous coronary interventions, and lipid core containing plaques that are suspected to be vulnerable can be distinguished from other types of plaques that are considered to be less likely to rupture and cause death. The method has been tested successfully in a prospective study using coronary autopsy specimens and comparing NIRS results to histologic analysis in a double-blind clinical study. This talk will present an overview of the NIRS Coronary Imaging System and the data validating its accuracy.

Goodrich will need the name and citizenship for each attendee. Please include this when you make a reservation. All are welcome to this talk regardless of citizenship.

Last Updated ( Tuesday, 28 July 2009 )
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Nov. 20, 2008 - Joseph Eberly PDF Print E-mail
2008

Schrödinger's Cat, Clauser's Interferometer, and Impossible Optics

OSA Presidential Speaker
Note: Meeting to be held at Goodrich

I will make an excursion into one of the longest-running frontier areas of physics, which is the  weird character of quantum mechanics itself. Illustrations will include a description of experiments with  the Clauser Interferometer, one of the new optical devices invented for study in this domain.  Schrödinger's Cat is no longer just an academic matter, and on-going studies are providing startling answers to questions about the reality of the natural world. I'll offer a proof, for example, showing that the square of the cosine of a real angle is larger than the cosine itself, thus contradicting high school trigonometry.

Goodrich will need the name and citizenship for each attendee. Please include this when you make a reservation. All are welcome to this talk regardless of citizenship.

Last Updated ( Tuesday, 28 July 2009 )
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Oct. 16, 2008, Steven Smith PDF Print E-mail
2008

A history of the Optical Print Display Hologram

The advent of the commercial Hologram industry in the early 1980's lead to the development of small to large format optical display holograms as large as 2 meters square, and has progressed to larger format digital holographic imaging technology in full color available today.  Where has the market gone?  Was this a promise unfulfilled or yet to be realized.

Last Updated ( Tuesday, 28 July 2009 )
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Feb. 19, 2009 - Ben Vakoc PDF Print E-mail
2008

 Optical frequency domain imaging
A new tool for studying tumor biology and evaluating cancer therapies

High resolution, intravital multiphoton microscopy has provided powerful mechanistic insights into health and disease, and has become a common instrument in the modern biological laboratory. The requisite high numerical aperture and exogenous contrast agents that enable multiphoton microscopy, however, result in a limited capacity to investigate substantial tissue volumes or to probe dynamic changes repeatedly over prolonged periods. Here, we introduce optical frequency domain imaging (OFDI) as an intravital microscopic tool that circumvents the technical limitations of multiphoton microscopy and, as a result, provides unprecedented access to previously unexplored, critically important aspects of tumor biology. We describe the operation of the OFDI instrument, and present measurements of tumor angiogenesis, lymphangiogenesis, and both vascular and cellular responses to therapy, thereby demonstrating the potential of OFDI to facilitate the exploration of physiological and pathological processes and the evaluation of treatment strategies.
Last Updated ( Tuesday, 28 July 2009 )
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Jan. 15, 2009 - Mordechai Rothschild PDF Print E-mail
2008

Advanced Lithography and the Semiconductor Industry Roadmap

Semiconductor devices are expected to continue their historic trend of diminishing size for at least several more device generations. Patterning at 65-, 45-, 32-nm and beyond is being enabled by new developments in optical lithography. “Conventional” 193-nm projection lithography will be replaced by liquid immersion lithography, double patterning processes, sophisticated mask design, and other technologies. Alternative lithographies, such as extreme ultraviolet (EUV) projection, electron-beam direct write, and nanoimprint, must compete with enhanced optical lithography in terms of cost, yield, and throughput. This talk will discuss the various aspects of sub-65 nm optical lithography, and place them in the broader context of the semiconductor industry roadmap. Topics will include prospects of high-index liquid immersion lithography, the applicability of double patterning, resist limitations, as well as new lithographic concepts. 

Last Updated ( Tuesday, 28 July 2009 )
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